Tuesday, January 25, 2011

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blessed thistle ELECTIVE PLAN FOR LIVER

Silybum marianum (L.)

The thistle is a biennial or annual medicinal plant is used as a traditional remedy for centuries in the problems of the liver.

The milk thistle is a plant to erect and vigorous, has large leaves, lobed, bright green in color, with bright white streaks and edge thorny and ciliate. The flowers are a beautiful violet are surrounded by bratee thorny and combined into large copolini . Flowering occurs in summer, and the plant can grow to one and a half high.
This plant character seminfestante particularly widespread in the Mediterranean area, principally in southern and central Italy, rarely in North Italy. It is found with relative ease in fallow fields, pastures, along the edges of the paths through the rubble.
it, you use the leaves, roots and seeds. The van leaves picked in spring and in a shady spot to dry and ventilated, while the roots are removed in the spring or autumn. Peel from the earth are dried after being cut to pieces. The seeds are harvested by shaking of the head dried.

The part of the plant that is used is the dried ripe fruit and leaves (less active).
This drug contains a 1.5 to 3% of flavonolignans collectively called silymarin, which
phytocomplex farmacologicamete is the main focus.
The major component of silymarin is silybin silibinina or a 50:50 mixture of silybin A and silybin B [1] as well silidianina [2], silicristina [3], and small amounts of isosilibina, too ' it as a mixture of diastereoisomers trans.

pharmacological properties

Antioxidant activity
silymarin and silibilina exert antioxidant activity in vitro reacting with free radicals
oxygen level of platelets, fibroblasts, and mitochondria liver. There is also an indirect effect related to the antioxidant capacity of the plant complex to inhibit cytochrome P450 activity which generates oxygen free radicals. Silymarin inhibits lipid peroxidation induced by oxygen free radicals on human red blood cells, causing the stabilization of the structure of the cell membrane. AMPciclico dependent phosphodiesterase is inhibited by the plant complex, this may be one of the possible anti-inflammatory mechanisms of action since the cAMP stabilizes lysosomal membranes and an increase in its concentration can reduce the degranulation
inflammatory cells.

hepatoprotective activity
There are many mechanisms of action called in to explain the hepatoprotective action of silymarin, some such as the reduction of lipid peroxides and free radical scavenger action, have already been listed. In addition, the literature reports the change of membrane properties and the reduction of liver fibrogenesis as additional protective factors. The sibilina binds to the regulatory subunit of RNA polymerase I-dependent DNA near the binding site of estrogen acts as an effector natural steroid, the increase in ribosomal RNA in the liver stimulates the formation of ribosomes and thus protein synthesis. The extract contains a large amount of phosphatidylcholine, which prevents the development of hepatic fibrosis.

anti-inflammatory activity
The main anti-inflammatory effect of silymarin appears to be related to its ability to inhibit nuclear factor-kB transcriptional (NF-kB) that regulates the expression of several molecules involved in inflammatory response, survival, growth and cell differentiation. In particular, NF-kB promotes the production of IL-1, IL-6, TNF, INF-γ and GM-CSF (granulocyte macrophage colony stimulating factor).
In leukocytes inhibits human basophil histamine release mediated by neutrophils. It also inhibits histamine release from rat peritoneal mast cells and Kupffer cells isolated from rat inhibited the synthesis of leukotriene B4. In vitro, the four isomers inhibited the activity of lipoxygenase and prostaglandin synthetase.

Antiviral activity
Although used as supportive therapy in liver diseases of viral origin, was not evidence of a direct activity against HCV.

antitumor activity
Silymarin has proved capable of reducing the proliferation of tumor cells of various types (prostate, ovary, breast, lung, skin and bladder). The main mode of action is due to the modulation of the expression of cyclins, CDK and CDKinhibitors.
was also recently found that silymarin reduces the increase in cell proliferation caused by UVB radiation, also inhibits the microvascular density, inflammation and angiogenic reactions.
In some types of cancer cells (melanoma), silymarin induces apoptosis.
antiangiogenic activity has been demonstrated in several types of cancer, in particular has been demonstrated that these molecules reduce the secretion of Vascular Endothelial Growth Factor in the cells of prostate cancer, breast and lung.
Nevertheless, through interaction with the genome and the modulation of gene expression of molecules such as MMP-2, u-PA, ERK1 / 2, AP-1 and NF-kB takes the phytocomplex Antimetastatic a very important role.

Clinical use
acute hepatitis and chronic
cirrhosis induced by alcohol, drugs and toxins
necrosis of liver cell
stenosis
fatty liver
poisoning

Basic:
in this short text we have referred to the active ingredients that qualify and motivate the work the thistle, but this is obviously "limited" in fact we will use and always up in each case the extraction of active ingredients but the plant, thistle, as a whole, therefore, always use macerated in hydroalcoholic extracts of fresh plant.

Dosage: 40-50 drops in a little water before meals three

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